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KMID : 0356420070250030129
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Journal of Korean Andrology
2007 Volume.25 No. 3 p.129 ~ p.134
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Effects of Chronic Treatment with a Type 5 Phosphodiesterase Inhibitor on Erectile Function in Diabetic Rats
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Cho Min-Chul
Paick Jae-Seung
Park Kwan-Jin
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Abstract
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Purpose: We investigated whether chronic treatment with a type 5 phosphodiesterase inhibitor (PDE5I) could suppress corporal apoptosis and improve erectile function in diabetic erectile dysfunction.
Materials and Methods: Sprague-Dawley rats (12 weeks old) were assigned into 1) normal control 2) diabetes, and 3) diabetes with PDE5I treatment groups (n=12 per group). After inducing diabetes with intraperitoneal injection of streptozotocin, the diabetic and PDE5I-treatment groups were treated with vehicle or PDE5I (mirodenafil, 10 mg/kg) for 4 weeks. To examine the effect on erectile response, 6 rats in each group underwent cavernosometry under cavernous nerve electrostimulation (2 V, 0.2 msec, 50 sec, 2.5∼20 Hz). The penile tissues from the remaining 6 rats were used for immunohistochemical evaluation of apoptosis.
Results: The diabetic group showed markedly lower mean intracavernosal pressure/mean arterial pressure (ICP/MAP) and area under the curve of cavernosometry than normal controls, whereas the diabetes with PDE5I treatment group showed normal results. Despite persistent hyperglycemia, PDE5I treatment significantly reduced the mean apoptotic index (39.6±4.6 vs 21.8±5.1, p＜0.05).
Conclusions: Chronic administration of PDE5I suppressed apoptosis of corporal smooth muscle and improved erectile function in a rat model of diabetic erectile dysfunction.
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KEYWORD
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Rat, Diabetes, Erectile dysfunction, Phosphodiesterase inhibitor
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